The campus is located 10 km (6.2 mi) from the Chennai Airport, 15 km (9.3 mi) from the Chennai Central Railway station, and is well connected by city buses. Thiruvanmiyur is the nearest station on the Chennai MRTS line.
The NITTTR Chennai campus features two entrances. The primary entrance is situated on the bustling Rajiv Gandhi Salai in Taramani, directly across from the Thiruvanmiyur MRTS Railway Station. It's conveniently located near the Rajiv Gandhi Salai–Thiruvanmiyur West Avenue Junction, a heavily trafficked intersection accommodating approximately 30,000 vehicles daily. Additionally, the campus is in close proximity to TIDEL Park, a prominent information technology (IT) park within Chennai.
Another entrance can be found in Tharamani, opposite the Spastics Society of Tamil Nadu and the International Tech Park, Chennai